Publications

Peer Reviewed Publications

Tanskanen, A. and Winslow, R. L. (2005). Integrative Structurally-detailed model of calcium dynamics in the cardiac diad. SIAM Journal of Multi-Scale Modeling and Simulation, submitted.

Yang, C. G., Granite, S. J., Van Eyk, J. and Winslow, R. L. (2005). Mascot HTML and XML Parser: An implementation of a novel object model for protein identification. Proteomics, submitted.

Granite, S. J., Yang, C., Ali, A., Robinson, D., Van Eyk, J. and Winslow, R. L. (2005). PROTEIN-DB2: a database for storing and querying primary proteomic data and subsequent analyses. Proteomics, submitted.

Cortassa, S., Aon, M. A., O’Rourke, B., Jacques, R., Tseng, H-J., Marban, E., and Winlsow, R. L. (2005) A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte. submitted.

Helm, P. A., Younes, L., Beg, F. M., Ennis, D. B., Leclercq, C., Faris, O. P., McVeigh, E., Kass, D., Miller, M. I. and Winslow, R. L. (2005). Evidence of structural remodeling in the dysynchronous failing heart. Circ. Res., in press.

Helm, P. A., Tseng, H. J., Younes, L., McVeigh, E. R., Winslow, R. L. (2005) 3D Diffusion Tensor Imaging and Ex-vivo Quantification of Cardiac Laminar Structure. Mag. Reson. Med., 2005 Sep 7; [Epub ahead of print].

Helm, P. A., Beg, M. F., Miller, M. I., Winslow, R. L. (2005) Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging. Annals NY Acad Sci., 1047: 296-307.

Tanskanen, A. J. Greenstein, J. L., O'Rourke, B., Winslow, R. L. (2005) The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophys. J., 88: 85-95.

Hinch, R., Greenstein, J. L. and Winslow, R. L. (2005). Multi-scale models of local control of calcium induced calcium release. Prog. Mol. Biol. Biophys., in press.

Helm, P. A., Tseng, H. J., Baumgartner, W. A. Jr., McVeigh, E and Winslow, R. L. (2005). High resolution 3D DTMRI of canine myocardium. Mag. Res. Imag., accepted

Cao, Y., Miller, M. I., Winslow, R. L. and Younes, L. (2005). Large deformation diffeomorphic metric mapping of vector fields. IEEE Trans. Med. Imaging., 24(9): 1216-1230.

Gao, Z., DiSilvestre, D., Halperin, V. L., Tian, Y., Winslow, R. L. and Tomaselli, G. F. (2005). Transcriptomic Profiling of the Canine Tachycardia-Induced Heart Failure Model: Global Comparison to Human and Murine Heart Failure. J. Mol. Cell. Cardiol, accepted.

Cao, Y., Miller, M. I. , Winslow, R. L. and Younes, L. (2005). Large Deformation Diffeomorphic Metric Mapping of Fiber Orientations. Proceedings of the 10th IEEE International Conference on Computer Vision, Beijing, China, accepted.

Tan, A. C., Naiman, D. Q., Xu, L., Winslow, R. L. and Geman, D. (2005). Simple decision rules for classifying human cancers from gene expression profiles. Bioinformatics. 2005 Aug 16; [Epub ahead of print]

Xu, L., Tan, A. C., Naiman, D. Q., Geman, D. and Winslow, R. L. (2005). Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data. Bioinformatics, 2005 Aug 30; [Epub ahead of print].

Tanskanen, A. J., Alvarez, L. H. R., Greenstein, J. L. and Winslow, R. L. (2005). How do current fluctuations affect action potential duration in cardiac myocytes? J. Theo. Biol., submitted.

Greenstein, J. L. and Winslow, R. L. (2005). Mechanisms underlying local control of excitation-contraction coupling in an efficient model of the cardiac ventricular myocyte. Biophys. J., submitted

Winslow, R. L. Cortassa, S. Greenstein, J. L. (2005) Using models of the myocyte for functional interpretation of cardiac proteomic data. J. Physiol., 563(1): 73-81.

Beg, F. M., Helm, P. A., McVeigh, E., Miller, M. I. and Winslow, R. L. (2004) Computational cardiac anatomy using magnetic resonance imaging. MRM, 52(5): 1167-1174.

Cortassa, S. Aon, M. Winslow, R. L. and O'Rourke, B. (2004) A mitochondrial oscillator dependent on reactive oxygen species. Biophys. J., 87(3): 2060-2073.

Geman, D., d'Avignon, C., Naiman, D. Q. and Winslow, R. L. (2004) Classifying gene expression profiles from pairwise mRNA Comparisons Statistical Applications in Genetics and Molecular Biology, 3(1): Article 19.

Hinch, R., Greenstein, J. L., Tanskanen, A. J., Xu, L. and Winslow, R. L. (2004) A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes. Biophys. J., 87(6): 3723-3736.

Winslow, R. L., and Greenstein, J. L. (2004) The ongoing journey to understand heart function through integrative modeling. Circ. Res. 95: 1135-1136.

Iyer, V., Mazhari, R. and Winslow, R. L. (2004) A computational model of the human left- ventricular epicardial myocyte. Biophys. J., 87(3): 1507-1525.

Yung, C. K., Halperin, V. L., Tomaselli, G. F., and Winslow, R. L. (2004) Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: Altered expression of apoptotic and cytoskeletal genes. Genomics, 83(2): 281-297.

Greenstein, J. L., Tanskanen, A. J. and Winslow, R. L. (2004) Modeling the actions of b-adrenergic signaling on excitation-contraction coupling processes. Ann. N.Y. Acad. Sci., 1015: 16-27.

Armoundis, A. A., Hobai, I. A., Tomaselli, G. F., Winslow, R. L., and O’Rourke, B. (2003) Role of sodium-calcium exchange in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ. Res., 93(1): 46-53.

dos Remedios, C. G., Liew, C. C., Allen, P. D., Winslow, R. L., Van Eyk, J. and Dunn, M. J. (2003) Genomics, proteomics and bioinformatics of human heart failure. J. Musc. Res. Cell Motility, 24(4-6): 251-260.

Winslow, R. L. and M. S. Boguski (2003) Genome Informatics: Current Status and Future Prospects Circ. Res., 92(2): 950-952.

Bober, M., Wiehe, K., Yung, C., Suzek, T. O., Lin, M., Baumgartner Jr., W. and Winslow, R. L. (2002) CaGE: Cardiac Gene Expression Knowledgebase. Bioinformatics, 18(7): 1013-1014.

Cortassa, S., Aon, M. A., Marban, E., Winslow, R. L. and O’Rourke, B. (2002) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J., 84(4): 2734-2755.

Greenstein, J. L. and Winslow, R. L. (2002) An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophys. J., 83(6): 2918-2945.

Mazhari, R., Nuss, H. B., Armoundis, A. A., Winslow, R. L., and Marban, E. (2002) Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. J. Clinic. Invest., 109(8): 1083-1090.

Mazhari, R., Greenstein, J. L., Winslow, R. L., Marbán, E., and Nuss, H. B. (2001) Molecular Interactions Between Two Long QT Syndrome Gene Products, HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis. Circ Res; 89: 33-38.

Winslow, R. L., Scollan, D. F., Greenstein, J., Yung, C., Baumgartner, W., Bhanot, G., Gresh, D. and Rogowitz, B. (2001) Mapping, modeling and visual exploration of structure-function relationships in the heart. IBM Systems Journal, 40(2): 342-359 .

Greenstein, J. L., Po, S., Wu, R., Tomaselli, G., and Winslow, R. L. (2000) Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ. Res., 87(11): 1026.

Holmes, A., Scollan, D., and Winslow, R. L. (2000) Direct histological validation of diffusion tensor MRI in formaldehyde-fixed myocardium. Magn. Res. Med., 44(1): 157-161.

Kohl, P, Noble, D., Winslow, R. L., and Hunter, P. (2000) Computational Modeling of Biological Systems: Tools and Vision . Phil. Trans. R. Soc. Lond., A., 358(1766): 579-610.

Rice, J. J., Jafri, S., and Winslow, R. L. (2000) Modeling short-term interval-force relations in cardiac muscle. Am. J. Physiol. Heart Circ. Physiol, 278(3): H913-H931.

Scollan, D., Holmes, A., Zhang, J. and Winslow, R. L. (2000) Reconstruction of cardiac ventricular geometry and fiber orientation using magnetic resonance imaging. Ann. Biomed. Eng., 28(8): 934-944.

Winslow, R. L. Greenstein, J., Tomaselli, G. F., and O’Rourke, B.(2000) Computational models of the failing myocyte: Relating altered gene expression to cellular function. Phil. Trans. Roy. Soc. A, 359(1783): 1187-1200.

Winslow, R. L., Scollan, D. F., Holmes, A., Yung, C. K., Zhang, J. and Jafri, M. S. (2000) Electrophysiological Modeling of Cardiac Ventricular Function: From Cell to Organ. Ann. Rev. Biomed. Eng., 2: 119-155.

Irvine, L., Jafri, M. S., and Winslow, R. L. (1999) Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation. Biophys. J., 76(4): 1868-1885.

Rice, J. J., Jafri, M. S., and Winslow, R. L. (1999) Modeling gain and gradedness of Ca2+ release in the functional unit of the cardiac diadic space. Biophys. J., 77(4): 1871-1884.

Rice, J. J., Winslow, R. L. and Hunter, W. C. (1999) Comparison of putative mechanisms in cardiac muscle: Length-dependence and dynamic responses. Am J Physiol., 276(5): H1734-H1754.

Steinmetz, P. and Winslow, R. L. (1999) Optimal detection of flash intensity differences using rod photocurrent observations. Neural Computation, 11(5): 1097-1111.

Winslow, R. L., Rice, J. J., Jafri, S., Marban, E., and O’Rourke, B. (1999) Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure II: Model Studies. Circ. Res., 84(5): 571-586.

Jafri, M. S., Rice, J. J., and Winslow, R. L. (1998) Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys., J., 74(3): 1149-1168.

Rice, J. J., Jafri, M. S., and Winslow, R. L. (1998) Modeling short-term interval-force relations in cardiac muscle. Ann. N. Y. Acad. Sci., 853: 345-349.

Rice, J. J., Winslow, R. L., Dekanski, J., and McVeigh, E. (1998) Model studies of the role of mechano-sensitive currents in the generation of cardiac arrhythmias. J Theor Biol., 190(4): 295-312.

Scollan, D. F., Holmes, A., Winslow, R. L., and Forder, J. (1998) Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. Am. J. Physiol., 275: H2308-H2318.

Winslow, R. L., Rice, J. J., and Jafri, S. (1998) Modeling the cellular basis of altered excitation-contraction coupling in heart failure. Prog. Biophys. Mol. Biol., 69(2-3): 497-514.

Zhang, H., Winslow, R. L., and Holden, A. V. (1998) Re-entrant excitation initiated in models of inhomogeneous atrial tissue. J. Theor.Biol., 191(3): 279-287.

Kohl, P., Varghese, A., Dekanski, J., Noble, D., and Winslow, R. L. (1996) Computational study of the impact of cardiac mechanosensitive fibroblasts on heart rhythm. Exp. Clin. Cardiol., 1(2): 80-86.

Lai, Y. C., and Winslow, R. L. (1995) Geometric properties of the chaotic saddle responsible for supertransients in spatiotemporal chaotic systems Physical Review Letters, 74(26): 5208-5211.

Winslow, R. L., Cai, D., Varghese, A., Lai, Y. C. (1995) Generation and propagation of normal and abnormal pacemaker activity in network models of cardiac sinus node and atrium. Chaos, Solitons, and Fractals, 5(3-4): 491-512 .

Lai, Y. C. and Winslow, R. L. (1994) Fractal basin boundaries in coupled map lattices. Physical Review E, 50(5): 3470-3473.

Cai, D., Winslow, R. L., and Noble, D. (1994) Effects of gap junction conductance on dynamics of sinoatrial node cells: Two-cell and large-scale network models IEEE Trans. BME, 41(3): 217-231.

Lai, Y. C. and Winslow, R. L. (1994) Extreme sensitive dependence on parameters and initial conditions in spatio-temporal chaotic dynamical systems. Physica D: Nonlinear Phenomena, 74(3-4): 353-371.

Lai, Y. C., Winslow, R. L., and Sachs, M. B. (1994) The functional role of excitatory and inhibitory interactions in chopper cells of the antero-ventral cochlear nucleus. Neural Computation., 6(6): 1126-1139.

Lai, Y. C., Winslow, R. L., and Sachs, M. B. (1994) A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus. Journal of Computational Neuroscience, 1(3): 167-194.

Lai, Y.-C., and Winslow, R. L. (1994) Riddled parameter space in spatio-temporal chaotic dynamical systems. Physical Review Letters, 72(11): 1640-1643.

Varghese, T., and Winslow, R. L. (1994) Dynamics of abnormal pacemaking activity in cardiac Purkinje fibers J. Theo. Biol., 168(4): 407-420.

Cai, D., Lai, Y. C., and Winslow, R. L. (1993) Complex dynamics in coupled cardiac pacemaker cells Physical Review Letters, 71(15): 2501-2504.

Varghese, T. and Winslow, R. L. (1993) Dynamics of the calcium subsystem in cardiac Purkinje fibers. Physica D: Nonlinear Phenomena, 68(3-4): 364-386.

Winslow, R. L., Kimball, A., Varghese, A., and Noble, D. (1993) Simulating cardiac sinus and atrial network dynamics on the Connection Machine. Physica

D: Nonlinear Phenomena, 64(1-3): 281-298.

Winslow, R. L., Noble, D., Varghese, A., Adlakha, C., and Hothyta, A. (1993) Generation and propagation of ectopic beats induced by Na-K pump inhibition in atrial network models. Proc. R. Soc. Lond. B., 254(1339): 55-61.

Winslow, R. L. and Knapp, A. G. (1991) Dynamic models of the retinal horizontal cell network. Prog. Biophys. Molec. Biol., 56(2): 107-133.

Winslow, R. L., and Ma, S. (1990) Bifurcation analysis of horizontal cell models: II. Network properties. J. Neurophysiol., 64(1): 248-261.

Sachs, M. B., Winslow, R. L. and Sokolowski, B. (1989) A computational model of auditory-nerve rate-level functions. Hearing Res., 41(1): 61-69.

Winslow, R. L. (1989) Bifurcation analysis of horizontal cell models: I. Properties of isolated cells. J. Neurophysiol, 62(3): 738-749.

Winslow, R. L., and Miller, R. F. (1989) An experimental and theoretical study of the effects of non-uniform membrane resistance on the shape of single-cell charging curves. Neurosci., 29(3): 761-771.

Winslow, R. L., Miller, R. F., and Ogden, T. E. (1989) The Functional Role of Spines in the Retinal Horizontal Cell Network. Proc. Natl. Acad. Sci., 86(1): 387-391.

Winslow, R.L. and Sachs, M.B. (1988) Single-tone intensity discrimination based on auditory-nerve rate responses in backgrounds of quiet, noise, and with stimulation of the crossed olivocochlear bundle. Hearing Res., 35(2-3): 165-189.

Winslow, R.L. and Sachs, M.B. (1987) Effect of electrical stimulation of the crossed olivo-cochlear bundle on auditory-nerve responses to tones in noise. J. Neurophysiol., 57(4): 1002-1021.

Book Chapters

Winslow, R. L., Greenstein, J. L. and Helm, P. A. (2005)., Biophysical Models of the Cardiovascular System. In: Systems Biology, Edts. I. Rigoutsos and G. Stephanopoulos, Springer Verlag Series on Advances in Biochemical Engineering/Biotechnology.

Winslow, R. L., Hinch, R. and Greenstein, J. L. (2005). Mechanisms and Models of cardiac Excitation-Contraction Coupling. In: Synapses and Muscle. Edt. J. Sneyd and A. Friedman,  Springer-Verlag, in press.

Systems Biology Section Editor (2004). The Wiley Interscience Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley and Sons, Ltd. Chichester, UK.

Winslow, R. L. (2003). Modeling Cardiac Function. In: Complex Systems in Biomedicine, Eds. T. Deisboeck, T. Kepler, Y. Kresh, Kluwer Academic Press, New York, NY 10013.

Winslow, R. L. (2003). Cellular Models. In: Databasing the Brain: Data to Knowledge, Eds. S. Subramaniam and S. Koslow, John Wiley & Sons, Ltd.

Noble, D. and Winslow, R. L. (1994). Reconstructing the heart: Network models of SA node - atrial interactions. In: Computational Biology of the Heart, Eds. AV Panfilov and AV Holden, Academic Publishers: John Wiley.

Noble, D., Brown, H. F., and Winslow, R. L. (1993). Propagation of pacemaker activity: Interaction between pacemaker cells and atrial tissue. In: Pacemaker Activity and Intercellular Communication, Edts. W. Giles and J. D. Huizinga, CRC Press.

Noble, D., Denyer, J. C., Brown, H. F., Winslow, R. L., and Kimball, A. (1992). Cardiac pacemaker activity: From single cells to modelling the heart. In: Heart Function in Health and Disease. B. Ostadal, edt. Kluwer Academic Press

Publishers, Assinippi Park, MA.

Noble, D., Denyer, J. C., Brown, H. F., Winslow, R. L., and Kimball, A. (1992). Modeling of cardiac rhythm: from single cells to massive networks. In: Coupled Oscillating Neurons, Eds. J. G. Taylor and C. L. T. Mannion, Springer-Verlag.

Winslow, R.L., Barta, P.E. and Sachs, M.B. (1987). Rate coding in the auditory-nerve. In: Auditory Processing of Complex Sounds. C.S. Watson and W. Yost, eds., New Jersey: Lawrence Erlbaum Associates, pp. 212-224.

Sachs, M.B., Winslow, R.L. and Blackburn, C.C. (1986). Representation of speech in the auditory periphery. In: Functions of the Auditory System, S. Hassler, ed., New York: John Wiley and Sons, Inc.

Conference Proceedings

Geman, D., D'Avignon, C., Naiman, D., Winslow, R. L. and Zeboulon, A. (2004) Gene expression comparisons for class prediction in cancer studies Proceedings of the 2004 Symposium: Computing Science and Statistics

Winslow, R. L., Helm, P., Baumgartner Jr., W., Peddi, S., Ratnanather, T., McVeigh, E., and Miller, M. I. (2002) Imaging-based integrative models of the heart: Closing the loop between experiment and simulation. In Silico Simulation of Biological Processes. Novartis Foundation Symposium, 247: 129-150

Bober, M. B., Delmar, P. Szak, S. T., Karaoz, U., White, J. A., Hudson, J., Boguski, M., Tomaselli, G. F. and Winslow, R. L. (2001) Gene Expression in Human Heart Failure: Microarray Analysis of Dilated Cardiomyopathy. Currents in Computational Molecular Biology 2001, pgs. 171-172. Les Publications CRM, Montreal

Bober, M. B., Suzek, T. O., Wiehe, K. and Winslow, R. L. (2001) The Human Cardiac Gene Expression Knowledgebase. Currents in Computational Molecular Biology 2001, pgs. 239-240. Les Publications CRM, Montreal

Gresh, D.L., Rogowitz, B.E., Winslow, R.L., Scollan, D.F., Yung, C.K. (2000) WEAVE: A system for visually linking 3D and statistical visualizations, applied to cardiac simulation and measurement data. IEEE Visualization, pgs. 489-492. Salt Lake City, Utah

Varghese, A. and Winslow, R. L. (1994) Ion Accumulation and Arrhythmogenesis in Networks of Cardiac Cells. Computers in Cardiology 1994, 397-400

Irvine, L. and Winslow, R. L. (1996) Numerical Studies of Use-Dependent Block of Cardiac Sodium Channels by Quinidine on Spiral Wave Reentry. Computers in Cardiology 1996, pgs. 613-616

Demir, S. S., O'Rourke, B., Tomaselli, G. F., Marban, E., and Winslow, R. L. (1996) Action potential variation in canine ventricle: A modeling study. Computers in Cardiology 1996, pgs. 221- 224

Winslow, R. L., and Varghese, A. (1994) Modeling the functional role of SA node - atrial interdigitation. Computers in Cardiology 1994, 649-652

Winslow, R. L., Cai, D., and Lai, Y. C. (1994) Network models of the SA node. Proc. IFAC Symp. Modeling and Control in Biomedical Systems, 86-91

Winslow, R. L., Cai, D., and Lai, Y. C. (1994) Factors controlling generation and propagation of pacemaker potentials in network models of mammalian SA node. Proc. of Supercomputing 1994, 560-569

Cai, D., Lai, Y. C.-, and Winslow, R. L. (1993) Periodicity, quasiperiodicity, and chaos in coupled cardiac cell models. Proc. SPIE International Symposium on Chaos in Biology and Medicine, 2036: 10-21

Cai, D., Winslow, R. L., and Noble, D. (1992) Effects of gap junction conductance on oscillation properties of coupled sino-atrial node cells In: Computers in Cardiology Proceedings 1992, 579-582

Noble, D., Winslow, R. L., Kimball, A., Varghese, A. (1992) Modeling the heart on the Connection Machine. Proc. of the Fourth International Exhibition and Conference on High Performance Computing, 10-17

Noble, D., Denyer, J., Winslow, R. L., and Kimball, A. (1991) Modeling of cardiac rhythm: From single cells to massive networks. Proc. 18th Intern. Symp. Cardiovasc. Electrophysiol., Korean Academy of Medical Sciences, 69-86

Kimball, A. L., and Winslow, R. L. (1990) Modeling the retinal horizontal cell layer on a massively parallel processor: A detailed neural network model. Proceedings of the Second IEEE Symposium on Parallel and Distributed Processing, 792-798